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Article

Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.

Redox biology - 1 Nov 2021

Li Zhuqing, Li Qi, Wang Li, Li Chao, Xu Mengping, Duan Yajun, Ma Likun, Li Tingting, Chen Qiao, Wang Yilin, Wang Yanxin, Feng Jiaxin, Yin Xuemei, Wang Xiaolin, Han Jihong, Lu Chengzhi

Abstract excerpt

OBJECTIVE: The disruption of mitochondrial redox homeostasis in endothelial cells (ECs) can cause chronic inflammation, a substantial contributor to the development of atherosclerosis. Chronic sympathetic hyperactivity can enhance oxidative stress to induce endothelial dysfunction. We determined if renal denervation (RDN), the strategy reducing sympathetic tone, can protect ECs by ameliorating mitochondrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34607159
DOI: 10.1016/j.redox.2021.102156
PMCID: PMC8498003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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