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Dynamic Ins2 Gene Activity Defines β-Cell Maturity States

28 Sept 2022

Abstract excerpt

Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states. We investigated the temporal kinetics of endogenous insulin gene activity using live cell imaging, with complementary experiments using FACS and single-cell RNA sequencing, in β-cells...

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PMID: 36170671
DOI: 10.2337/db21-1065

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