Molecular phenotyping of single pancreatic islet leader beta cells by “Flash-Seq”

Abstract excerpt

Spatially-organized increases in cytosolic Ca2+ within pancreatic beta cells in the pancreatic islet underlie the stimulation of insulin secretion by high glucose. Recent data have revealed the existence of subpopulations of beta cells including “leaders” which initiate Ca2+ waves. Whether leader cells possess unique molecular features, or localisation, is unknown. High speed confocal Ca2+ imaging was used to...

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