Article

POINT Technology Illuminates the Processing of Polymerase-Associated Intact Nascent Transcripts

2020-11-10

Abstract excerpt

<h4>SUMMARY</h4> Mammalian chromatin is the site of both RNA polymerase II (Pol II) transcription and coupled RNA processing. However, molecular details of such co-transcriptional mechanisms remain obscure, partly due to technical limitations in purifying authentic nascent transcripts. We present a new approach to purify and profile nascent RNA, called Polymerase Intact Nascent Transcript (POINT) technology. This...

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Literature Corpus work: 51690cb0-8227-58c8-aa27-e09247d5bac8
DOI: 10.1101/2020.11.09.374108

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