Article
The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.
American journal of physiology. Renal physiology - 1 Apr 2006
Erdman Andrew R, Mangravite Lara M, Urban Thomas J, Lagpacan Leah L, Castro Richard A, de la Cruz Melanie, Chan Wendy, Huang Conrad C, Johns Susan J, Kawamoto Michiko, Stryke Douglas, Taylor Travis R, Carlson Elaine J, Ferrin Thomas E, Brett Claire M, Burchard Esteban G, Giacomini Kathleen M
Abstract excerpt
The human organic anion transporter, OAT3 (SLC22A8), plays a critical role in renal drug elimination, by mediating the entry of a wide variety of organic anions, including a number of commonly used pharmaceuticals, into the renal proximal tubular cells. To understand the nature and extent of genetic variation in OAT3, and to determine whether such variation affects its function, we identified OAT3 variants in a...
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