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Article

Disruption of mitochondrial complex I induces progressive parkinsonism.

Nature - 1 Nov 2021

González-Rodríguez Patricia, Zampese Enrico, Stout Kristen A, Guzman Jaime N, Ilijic Ema, Yang Ben, Tkatch Tatiana, Stavarache Mihaela A, Wokosin David L, Gao Lin, Kaplitt Michael G, López-Barneo José, Schumacker Paul T, Surmeier D James

Abstract excerpt

Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the substantia nigra is a hallmark of Parkinson's disease1. Yet, whether this change contributes to Parkinson's disease pathogenesis is unclear2. Here we used intersectional genetics to disrupt the function of MCI in mouse dopaminergic neurons. Disruption of MCI induced a Warburg-like shift in metabolism that enabled neuronal...

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Identifiers

PMID: 34732887
DOI: 10.1038/s41586-021-04059-0
PMCID: PMC9189968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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