Article

Mapping the developing human immune system across organs

2022-01-18

Abstract excerpt

Recent advances in single cell genomics technologies have facilitated studies on the developing immune system at unprecedented scale and resolution. However, these studies have focused on one or a few organs and were thus limited in understanding the developing immune system as a distributed network across tissues. Here, we profiled prenatal haematopoietic organs, lymphoid organs and non-lymphoid tissues using a c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 26ee8478-f6fd-525f-857a-7f67a5406a4f
DOI: 10.1101/2022.01.17.476665

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping the developing human immune system across organsDOI 10.1101/2022.01.17.476665Read

Early human lung immune cell development and its role in epithelial cell fateSemantic proximity Read

Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T CellsSemantic proximity Read

Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cellsSemantic proximity Read

Decoding the development of the blood and immune systems during human fetal liver haematopoiesisSemantic proximity Read

Distinct tissue-dependent composition and gene expression of human fetal innate lymphoid cellsSemantic proximity Read

Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transitionSemantic proximity Read

Single-cell profiling identifies a spectrum of human unconventional intraepithelial T lineage cellsSemantic proximity Read

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signaturesSemantic proximity Read

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesisSemantic proximity Read

Decoding human B cell ontogeny in prenatal and adult bone marrow and in vitro models via single-cell multiomicsSemantic proximity Read

Diversity of human NK cell developmental pathways defined by single-cell analyses.Semantic proximity Read

Transcriptome profiling of human thymic CD4+ and CD8+ T cells compared to primary peripheral T cellsSemantic proximity Read