TRPC6-Mediated Zn²⁺ Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells

Abstract excerpt

Vascular smooth muscle cells (VSMCs) can dynamically change their phenotype between con-tractile and synthetic forms in response to environmental stress, which is pivotal in maintaining vascular homeostasis and mediating pathological remodeling of blood vessels. We previously reported that suppression of canonical transient receptor potential 6 (TRPC6) activation by Ca2+ entry sustains VSMCs contractile phenotype...

Topics

Open a Topic to create a Post that cites this publication.

• Calcium
• Calcium Signaling
• Cardiovascular, Neuropeptides, and Oxidative Stress Research
• Gene Expression Regulation
• Ion Channels and Receptors
• Muscle Contraction
• Muscle, Smooth, Vascular
• Phenotype

Identifiers and source

Literature Corpus work

15b8d7fb-3766-5370-add3-2f547ceaff7f

DOI

10.20944/preprints202412.2492.v1