Article
TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology.
Biochemical pharmacology - 1 Oct 2012
Abriel Hugues, Syam Ninda, Sottas Valentin, Amarouch Mohamed Yassine, Rougier Jean-Sébastien
Abstract excerpt
The transient receptor potential channel (TRP) family comprises at least 28 genes in the human genome. These channels are widely expressed in many different tissues, including those of the cardiovascular system. The transient receptor potential channel melastatin 4 (TRPM4) is a Ca(2+)-activated non-specific cationic channel, which is impermeable to Ca(2+). TRPM4 is expressed in many cells of the cardiovascular...
Topics
- Animals
- Cardiovascular Agents
- Cardiovascular Diseases
- Cardiovascular System
- Gene Expression Regulation
- Genetic Variation
- Humans
- TRPM Cation Channels