Article
The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease.
Pflugers Archiv : European journal of physiology - 1 Aug 2008
House Suzanne J, Potier Marie, Bisaillon Jonathan, Singer Harold A, Trebak Mohamed
Abstract excerpt
Calcium (Ca(2+)) is a highly versatile second messenger that controls vascular smooth muscle cell (VSMC) contraction, proliferation, and migration. By means of Ca(2+) permeable channels, Ca(2+) pumps and channels conducting other ions such as potassium and chloride, VSMC keep intracellular Ca(2+) levels under tight control. In healthy quiescent contractile VSMC, two important components of the Ca(2+) signaling...
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