Article

Constitutive Inhibition of Transient Receptor Potential Canonical Type 6 (TRPC6) by O-GlcNAcylation at Threonine-221

2022-06-15

Abstract excerpt

<h4>ABSTRACT</h4> Transient receptor potential canonical type 6 (TRPC6) is a non-voltage gated cation channel that principally conducts calcium to regulate signaling in cardiac, vascular, neuronal and other cells. Abnormally increased TRPC6 expression/conductance and genetic gain of function mutations contribute to fibrosis, hypertrophy, proteinuria, and edema, notably linked to its stimulation of nuclear factor...

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Literature Corpus work: 91e471e1-4752-5aa9-857d-55f3c007080d
DOI: 10.1101/2022.06.15.496344

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