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Article

TRPV4 maintains the contractile phenotype of VSMCs by regulating CPI-17.

Biochemical pharmacology - 1 Oct 2025

Chen Jiani, Chu Yuan, Lan Yihui, Wan Jie, Zhang Yizhi, Liu Yuan, Yu Fan, Feng Lei, Zhu Yifei

Abstract excerpt

Early vascular lesions are closely associated with the phenotypic switching of vascular smooth muscle cells (VSMCs). Transient receptor potential vanilloid family member 4 (TRPV4) calcium channels are crucial for regulating vascular function. However, whether they contribute to the phenotypic switching of VSMCs remains unknown. Therefore, this study used a smooth muscle-specific TRPV4 knockout mouse model...

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Topics

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Share to Myocytes, Smooth Muscle
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Contraction

Share to Muscle Proteins

Share to Muscle, Smooth, Vascular

Share to Protein Phosphatase 1

Share to TRPV Cation Channels

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Source

Identifiers

PMID: 40619010
DOI: 10.1016/j.bcp.2025.117107

Genes

TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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