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Article

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.

Nature communications - 24 Jul 2018

Sasaguri Hiroki, Nagata Kenichi, Sekiguchi Misaki, Fujioka Ryo, Matsuba Yukio, Hashimoto Shoko, Sato Kaori, Kurup Deepika, Yokota Takanori, Saido Takaomi C

Abstract excerpt

Base Editor (BE) and Target-AID (activation-induced cytidine deaminase) are engineered genome-editing proteins composed of Cas9 and cytidine deaminases. These base-editing tools convert C:G base pairs to T:A at target sites. Here, we inject either BE or Target-AID mRNA together with identical single-guide RNAs (sgRNAs) into mouse zygotes, and compare the base-editing efficiencies of the two distinct tools in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30042426
DOI: 10.1038/s41467-018-05262-w
PMCID: PMC6057936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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