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Article

Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium.

Gut - 1 Jun 2022

Fennell Lochlan, Kane Alexandra, Liu Cheng, McKeone Diane, Hartel Gunter, Su Chang, Bond Catherine, Bettington Mark, Leggett Barbara, Whitehall Vicki

Abstract excerpt

OBJECTIVE: Sessile serrated lesions (SSLs) are common across the age spectrum, but the BRAF mutant cancers arising occur predominantly in the elderly. Aberrant DNA methylation is uncommon in SSL from young patients. Here, we interrogate the role of ageing and DNA methylation in SSL initiation and progression. DESIGN: We used an inducible model of Braf mutation to direct recombination of the oncogenic Braf V637E...

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Share to Aged
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Polyps

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Share to Intestinal Mucosa

Share to Proto-Oncogene Proteins B-raf

Source

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Identifiers

PMID: 34230216
DOI: 10.1136/gutjnl-2020-322166
PMCID: PMC9120393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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