Article

Adaptation to volumetric compression drives hepatoblastoma cells to an apoptosis-resistant and invasive phenotype

2023-10-10

Abstract excerpt

Liver cancer involves tumor cells rapidly growing within a packed tissue environment. Patient tumor tissues reveal densely packed and deformed cells, especially at tumor boundaries, indicative of physical crowding and compression. It is not well understood how these physical signals modulate tumor evolution and therapeutic susceptibility. Here we investigate the impact of volumetric compression on liver cancer (He...

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Literature Corpus work: 156f536f-a47c-5043-b0b5-36194f011bbc
DOI: 10.1101/2023.10.08.561453

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