Metabolic starvation–induced cell swelling drives solid stress in tumors

Abstract excerpt

Solid stress shapes tumor growth, invasion, and therapeutic response, yet its physical origin and clinical relevance remain unclear. Here, we develop a mechano–electro–osmotic model integrating metabolic gradients, ion transport, and cellular mechanics to explain residual solid stress emergence in tumor spheroids, common models of solid tumors. We show that solid stress arises predominantly from osmotic cell swell...

Topics

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• Cell Proliferation
• Drug Resistance, Neoplasm
• Ecosystem
• Extracellular Matrix
• Mutation
• Neoplasms
• Phenotype
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

a750c0e2-98ce-5761-99f1-d52317138e13

DOI

10.64898/2026.02.05.704098