Article

Lipid droplets are intracellular mechanical stressors that promote hepatocyte dedifferentiation

2022-08-27

Abstract excerpt

Matrix stiffening and external mechanical stress have been linked to disease and cancer development in multiple tissues, including the liver, where cirrhosis (which increases stiffness markedly) is the major risk factor for hepatocellular carcinoma. Patients with non-alcoholic fatty liver disease and lipid-droplet-filled hepatocytes, however, can develop cancer in non-cirrhotic, relatively soft tissue. Here, we sh...

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Literature Corpus work: 6444de24-55bd-5a44-a3b5-28f96c6d1e21
DOI: 10.1101/2022.08.27.505524

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