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Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP

23 Jul 2019

Abstract excerpt

Physical cues are vital in determining cellular fate in cancer. In vitro 3D culture do not replicate forces present in vivo. These forces including tumor interstitial fluid pressure and matrix stiffness behave as switches in differentiation and metastasis, which are intricate features of cancer stem cells (CSCs). Gravity determines the effect of these physical factors on cell fate and functions as evident from...

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PMID: 31337825
DOI: 10.1038/s41598-019-47116-5

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