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Article

Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer.

Cancer research - 15 Aug 2025

Gong Xiangyu, Ogino Noriyoshi, Leite M Fátima, Zhang Dingyao, Chen Zehua, Nguyen Ryan Y, Liu Raymond, Kruglov Emma, Flores Kaitlin, Cabral Aidan T, Moreira de M Mendes Gabriel, Ehrlich Barbara E, Mak Michael

Abstract excerpt

Physical constraints like compression influence cancer cell invasion and transcriptional dynamics in various tumors. Liver cancer is characterized by the rapid proliferation of tumor cells within a densely packed tissue matrix, subjecting the cancer cells to crowding and compression. The highly dysregulated mechanical environment highlights the need to elucidate the broader impact of compression on liver cancer...

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Identifiers

PMID: 40387600
DOI: 10.1158/0008-5472.CAN-24-0859
PMCID: PMC12354003

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