Article

<i>SMARCA4</i> mutation induces tumor cell-intrinsic defects in enhancer landscape and resistance to immunotherapy

2024-06-22

Abstract excerpt

Cancer genomic studies have identified frequent alterations in components of the SWI/SNF (SWItch/Sucrose Non- Fermenting) chromatin remodeling complex including SMARCA4 and ARID1A . Importantly, clinical reports indicate that SMARCA4 -mutant lung cancers respond poorly to immunotherapy and have dismal prognosis. However, the mechanistic basis of immunotherapy resistance is unknown. Here, we corroborated the cli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4cc8d9f3-0e51-5dc8-9a83-1c43541bf231
DOI: 10.1101/2024.06.18.599431

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>SMARCA4</i> mutation induces tumor cell-intrinsic defects in enhancer landscape and resistance to immunotherapyDOI 10.1101/2024.06.18.599431Read

Mutation of SMARCA4 Induces Cancer Cell-Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy.Semantic proximity Read

SMARCA4 mutations and expression in lung adenocarcinoma: prognostic significance and impact on the immunotherapy response.Semantic proximity Read

A Pan-Cancer Analysis of SMARCA4 Alterations in Human Cancers.Semantic proximity Read

Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer.Semantic proximity Read

<i>SMARCA4</i> Mutations in <i>KRAS</i>-mutant Lung Adenocarcinoma: A Multi-cohort AnalysisSemantic proximity Read

The role of SMARCA4 in lung cancerSemantic proximity Read

SMARCA4 supports the oncogenic landscape of <i>KRAS</i> -driven lung tumorsSemantic proximity Read

SMARCA4 mutations in KRAS-mutant lung adenocarcinoma: a multi-cohort analysis.Semantic proximity Read

A Critical Review of the Impact of SMARCA4 Mutations on Survival Outcomes in Non-Small Cell Lung CancerSemantic proximity Read

Impact of Mutations in Subunit Genes of the Mammalian SWI/SNF Complex on Immunological Tumor Microenvironment.Semantic proximity Read

Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities.Semantic proximity Read

Clinical characteristics and association with immunotherapy outcomes in SMARCA4-deficient NSCLCSemantic proximity Read