Article
Mutational landscape of SWI/SNF complex genes reveal correlation to predictive biomarkers for immunotherapy sensitivity in lung adenocarcinoma patients.
ESMO open - 1 Jun 2023
Xu H, Chen H-C, Yang L, Yang G, Liang L, Yang Y, Tang H, Bao H, Wu X, Shao Y, An G, Wang Y
Abstract excerpt
BACKGROUND: The search for prognostic biomarkers indicating sensitivity to immunotherapy in lung adenocarcinoma patients has zeroed in on genes in the switch/sucrose non-fermentable (SWI/SNF) pathway. The mutational profiles of key genes are not clearly defined, however, and no comparisons have been conducted on whether mutations in the genes involved provide the same predictive value. METHODS: In this study,...
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