Article

Altered heparan sulfate in ageing and dementia : a potential axis for the dysregulation of BACE-1 in Alzheimer's disease

2017-01-01

Abstract excerpt

Alzheimer’s disease (AD) is characterised by amyloid plaques composed of amyloid-beta (Aβ), the cleavage product of the amyloid precursor protein (APP) by the protease beta-secretase (BACE- 1). Heparan sulfate (HS) inhibits BACE-1 and holds potential as a new drug discovery target; in vivo HS may act as a brake on the generation of Aß via regulation of BACE-1. Previous work has identified the sulfate moieties in H...

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Literature Corpus work: 1554303b-cc85-52f8-9088-063fd1b51b59
DOI: 10.17638/03006939

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