Article

Chemical biology tools for structure-function studies on heparan sulphates : decoding specificity in FGF signalling

2017-01-01

Abstract excerpt

Fibroblast growth factors (FGFs) regulate a broad spectrum of biological processes and aberrant FGF signalling has been linked to many disorders and diseases. Heparan sulphate (HS) is a highly sulphated glycosaminoglycan, which regulates the activity of its protein ligands, mainly through anionic interactions. The interactions between HS, FGF and FGF receptors (FGFRs) depend on the size and the spatial distributio...

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Literature Corpus work: c9052125-7430-59ae-ac2d-f5b56346df22
DOI: 10.17638/03006301

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