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Article

Rapid oligomer formation of human muscle acylphosphatase induced by heparan sulfate.

Nature structural & molecular biology - 22 Apr 2012

Motamedi-Shad Neda, Garfagnini Tommaso, Penco Amanda, Relini Annalisa, Fogolari Federico, Corazza Alessandra, Esposito Gennaro, Bemporad Francesco, Chiti Fabrizio

Abstract excerpt

Many human diseases are caused by the conversion of proteins from their native state into amyloid fibrils that deposit in the extracellular space. Heparan sulfate, a component of the extracellular matrix, is universally associated with amyloid deposits and promotes fibril formation. The formation of cytotoxic prefibrillar oligomers is challenging to study because of its rapidity, transient appearance and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22522822
DOI: 10.1038/nsmb.2286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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