Article

Structure-Guided Docking of Benzene-1,3-disulfonic Acid to the ApoE-HSPG Binding Site at Arginine 146 as a Christchurch-Mimetic Therapeutic Strategy for Alzheimer’s Disease

2025-04-24

Abstract excerpt

<title>Abstract</title> <p>Background: The APOΕ3 Christchurch (APOΕ3Ch) variant, characterized by an R136S substitution, confers protection against Alzheimer’s disease (AD) by reducing Apolipoprotein E (ApoE) binding to heparan sulfate proteoglycans (HSPGs), thereby limiting tau propagation. While antibody-based strategies mimicking this variant have shown promise, small-molecule approaches to disrupt the ApoE–HS...

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Literature Corpus work: 1f95a92c-3c57-52c8-8281-f5e915fdd2db
DOI: 10.21203/rs.3.rs-6515132/v1

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Structure-Guided Docking of Benzene-1,3-disulfonic Acid to the ApoE-HSPG Binding Site at Arginine 146 as a Christchurch-Mimetic Therapeutic Strategy for Alzheimer’s DiseaseDOI 10.21203/rs.3.rs-6515132/v1Read

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