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Article

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

7 Jan 2010

Abstract excerpt

Heparan sulfate (HS) has been found associated with amyloid deposits, including the toxic amyloid-beta (Abeta) peptide aggregates in cerebral vasculature and neuronal tissues in patients with Alzheimer's disease. However, the pathophysiological significance of the HS-Abeta interaction has remained unclear. In the present study, we applied cell models to gain insight into the roles of HS in relation to Abeta...

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PMID: 20053627
DOI: 10.1093/glycob/cwp205

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