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Article

Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site.

The Journal of biological chemistry - 15 Jan 2010

Hoopes James T, Liu Xuying, Xu Xiaomeng, Demeler Borries, Folta-Stogniew Ewa, Li Chris, Ha Ya

Abstract excerpt

The amyloid beta-peptide deposit found in the brain tissue of patients with Alzheimer disease is derived from a large heparin-binding protein precursor APP. The biological function of APP and its homologs is not precisely known. Here we report the x-ray structure of the E2 domain of APL-1, an APP...

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Identifiers

PMID: 19906646
DOI: 10.1074/jbc.M109.018432
PMCID: PMC2804372

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19906646-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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