Article

C-terminal disulfide bond in SUN2 regulate dynamic remodeling of LINC complexes at the nuclear envelope

2022-06-10

Abstract excerpt

The LINC complex tethers the cell nucleus to the cytoskeleton to regulate mechanical forces during cell migration, differentiation, and diseases. The function of LINC complexes relies on the interaction between highly conserved SUN and KASH proteins that form higher-order assemblies capable of load bearing. These structural details have emerged from in vitro assembled LINC complexes however, the principles of in...

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Identifiers and source

Literature Corpus work: 15235707-5b0a-5eb8-9c0b-71a7faeb4508
DOI: 10.1101/2022.06.08.495410

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