Article

Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis

2019-04-17

Abstract excerpt

The cardiomyocyte cytoskeleton, including the sarcomeric contractile apparatus, forms a cohesive network with cellular adhesions at the plasma membrane and nuclear-cytoskeletal linkages (LINC complexes) at the nuclear envelope. Human cardiomyopathies are genetically linked to the LINC complex and A-type lamins, but an full understanding of disease etiology in these patients is lacking. Here we show SUN2-null mice...

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Literature Corpus work: 38fc8218-7f81-5a80-859b-1fafaf9ae278
DOI: 10.1101/612150

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