Article

SUN2 mediates epigenetic remodeling to drive mechanotransduction during skin fibrosis

2026-03-20

Abstract excerpt

Fibrosis involves sustained changes in fibroblast gene expression, leading to excessive extracellular matrix (ECM) deposition and progressive tissue stiffening. Although matrix stiffness is a potent regulator of cell fate and transcription, it is not clear how nuclear mechanosensing contributes to fibrosis. Here, we define a central role for SUN2, a component of linker of nucleoskeleton and cytoskeleton (LINC) com...

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Literature Corpus work: 835feb55-7a1e-5a4b-95d3-84eb8e33b519
DOI: 10.64898/2026.03.19.712957

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