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Article

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

23 Aug 2019

Abstract excerpt

Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 from activated Cullins. Here we present structures of the neddylated and deneddylated CSN-CRL2 complexes by combining single-particle cryo-electron microscopy (cryo-EM) with chemical cross-linking mass spectrometry (XL-MS). These structures...

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PMID: 31444342
DOI: 10.1038/s41467-019-11772-y

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