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Article

Structural insights into SUN-KASH complexes across the nuclear envelope.

Cell research - 1 Oct 2012

Wang Wenjia, Shi Zhubing, Jiao Shi, Chen Cuicui, Wang Huizhen, Liu Guoguang, Wang Qiang, Zhao Yun, Greene Mark I, Zhou Zhaocai

Abstract excerpt

Linker of the nucleoskeleton and the cytoskeleton (LINC) complexes are composed of SUN and KASH domain-containing proteins and bridge the inner and outer membranes of the nuclear envelope. LINC complexes play critical roles in nuclear positioning, cell polarization and cellular stiffness. Previou...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22945352
DOI: 10.1038/cr.2012.126
PMCID: PMC3463262

Genes

SUN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22945352-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Structural insights into SUN-KASH complexes across the nuclear envelope.PMID 22945352Read ↗

A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.Semantic proximity Read ↗

C-terminal disulfide bond in SUN2 regulate dynamic remodeling of LINC complexes at the nuclear envelopeSemantic proximity Read ↗

SUN5 forms a regular protein lattice reinforcing the sperm head-tail junctionSemantic proximity Read ↗

<i>In-cell</i> structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cellsSemantic proximity Read ↗

The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.Semantic proximity Read ↗

Loss of <i>Sun2</i> ablates nuclear mechanosensing-driven extracellular matrix production and mitigates lung fibrosisSemantic proximity Read ↗

Nuclear SUN2 coordinates endothelial cell-matrix interactions to regulate blood vessel homeostasis and barrier functionSemantic proximity Read ↗

Targeting of the SUN protein Mps3 to the inner nuclear membrane by the histone variant H2A.Z.Semantic proximity Read ↗

Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization.Semantic proximity Read ↗

SUN2 mediates epigenetic remodeling to drive mechanotransduction during skin fibrosisSemantic proximity Read ↗

Life at the crossroads: the nuclear LINC complex and vascular mechanotransductionSemantic proximity Read ↗

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.Semantic proximity Read ↗

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