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Article

A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.

Molecular biology of the cell - 8 Aug 2018

Jahed Zeinab, Vu Uyen T, Fadavi Darya, Ke Huimin, Rathish Akshay, Kim Samuel C J, Feng Wei, Mofrad Mohammad R K

Abstract excerpt

Linkers of the nucleoskeleton and cytoskeleton are key molecular complexes that span the nuclear envelope (NE) and provide a direct linkage between the nucleoskeleton and cytoskeleton. Two major components of these complexes are members of the SUN and KASH protein families that interact in the perinuclear space to allow the transmission of mechanochemical signals across the NE. Structural details of the mammalian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29995584
DOI: 10.1091/mbc.E18-04-0266
PMCID: PMC6232973

Genes

SUN2

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Related research

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A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.PMID 29995584Read ↗

Structural insights into SUN-KASH complexes across the nuclear envelope.Semantic proximity Read ↗

C-terminal disulfide bond in SUN2 regulate dynamic remodeling of LINC complexes at the nuclear envelopeSemantic proximity Read ↗

Loss of <i>Sun2</i> ablates nuclear mechanosensing-driven extracellular matrix production and mitigates lung fibrosisSemantic proximity Read ↗

Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization.Semantic proximity Read ↗

<i>In-cell</i> structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cellsSemantic proximity Read ↗

SUN5 forms a regular protein lattice reinforcing the sperm head-tail junctionSemantic proximity Read ↗

Nuclear SUN2 coordinates endothelial cell-matrix interactions to regulate blood vessel homeostasis and barrier functionSemantic proximity Read ↗

Regulated Degradation of the Inner Nuclear Membrane Protein SUN2 Maintains Nuclear Envelope Architecture and FunctionSemantic proximity Read ↗

SUN2 mediates epigenetic remodeling to drive mechanotransduction during skin fibrosisSemantic proximity Read ↗

The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.Semantic proximity Read ↗

Targeting of the SUN protein Mps3 to the inner nuclear membrane by the histone variant H2A.Z.Semantic proximity Read ↗

Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosisSemantic proximity Read ↗

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