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Article

Cellular Senescence: The Sought or the Unwanted?

Trends in molecular medicine - 1 Oct 2018

Sun Yu, Coppé Jean-Philippe, Lam Eric W-F

Abstract excerpt

Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought to be an autonomous tumor-suppressor mechanism. During senescence, cells develop distinctive metabolic and signaling features, together referred to as the senescence-associated secretory phenotype (SASP). The SASP is implicated in several aging-related pathologies, including various malignancies. Accumulating evidence...

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Identifiers

PMID: 30153969
DOI: 10.1016/j.molmed.2018.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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