Article

Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response

2024-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Triple-negative breast cancers (TNBC), associated with poor prognosis and high tumour recurrence, are often-treated with taxanes in first-line treatment regimens. However, acquired disease resistance can often set in, hampering clinical efficacy. One avenue that could engender therapy resistance is therapy-induced senescence (TIS), as they represent a population of residual disease and are highl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f86342a-0bb1-55ef-9434-de0493388d93
DOI: 10.1101/2024.03.29.586905

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory responseDOI 10.1101/2024.03.29.586905Read

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesiclesSemantic proximity Read

Therapy-induced senescence in breast cancer: an overviewSemantic proximity Read

Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapySemantic proximity Read

Harnessing the interaction between redox signaling and senescence to restrain tumor drug resistanceSemantic proximity Read

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomesSemantic proximity Read

Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer.Semantic proximity Read

Senescence-Induced Chemoresistance in Triple Negative Breast Cancer and Evolution-Based Treatment StrategiesSemantic proximity Read

Senescence and the tumor-immune landscape: Implications for cancer immunotherapy.Semantic proximity Read

A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancerSemantic proximity Read

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectivesSemantic proximity Read

Therapy-induced senescent tumor cells in cancer relapseSemantic proximity Read

Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer.Semantic proximity Read