Article

Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs

2021-07-11

Abstract excerpt

<h4>ABSTRACT</h4> PIWI-interacting small RNAs (piRNAs) protect the germline genome and are essential for fertility. Previously, we showed that ribosomes guide the biogenesis of piRNAs from long non-coding RNAs (lncRNAs) after translating the short open reading frames (ORFs) near their 5’ cap. It remained unclear, however, how ribosomes proceed downstream of ORFs and how piRNA precursors distinguish from other RNA...

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Literature Corpus work: 14ef7a27-8f34-5d4e-a081-4d6a01a336bd
DOI: 10.1101/2021.07.10.451906

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