Article

HPV as a Molecular Hacker: How the Virus Hijacks Transcription Factors to Trigger Cancer

2025-06-06

Abstract excerpt

Human Papillomavirus (HPV), particularly high-risk strains like HPV16 and HPV18, is a leading cause of cervical and other epithelial cancers. While the oncogenic roles of viral proteins E6 and E7 are well established, the broader impact of HPV on host transcriptional regulation remains incompletely understood. This study investigates the hypothesis that conserved HPV genomic motifs may sequester human transcriptio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14dec71c-3af1-5e4e-b6f7-9079ada11867
DOI: 10.20944/preprints202506.0511.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HPV as a Molecular Hacker: How the Virus Hijacks Transcription Factors to Trigger CancerDOI 10.20944/preprints202506.0511.v1Read

Virus-host interaction: investigating novel transcription factors involved in coupling HPV life cycle and epithelial differentiationSemantic proximity Read

Repression of <i>CADM1</i> transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactionsSemantic proximity Read

Human papillomavirus integration transforms chromatin to drive oncogenesisSemantic proximity Read

ZNF582 inactivation unleashes HERVH-driven NF-kB signaling in cervical cancerSemantic proximity Read

Recurrent Integration of Human Papillomavirus Genomes at Transcriptional Regulatory HubsSemantic proximity Read

Cis‐regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancersSemantic proximity Read

Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.Semantic proximity Read

Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancersSemantic proximity Read

Post-Transcriptional Gene Regulation by HPV 16E6 and Its Host Protein PartnersSemantic proximity Read

HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expressionSemantic proximity Read

Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubsSemantic proximity Read

The HPV Induced Cancer Resource (THInCR): a Suite of Tools for Investigating HPV-Dependent Human CarcinogenesisSemantic proximity Read