Article

Repression of <i>CADM1</i> transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions

2024-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Upon infection, human papillomavirus (HPV) manipulates host cell gene expression to create an environment that is supportive of a productive and persistent infection. The virus-induced changes to the host cell’s transcriptome are thought to contribute to carcinogenesis. Here, we show by RNA-sequencing that oncogenic HPV18 episome replication in primary human foreskin keratinocytes (HFKs) drives...

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Literature Corpus work: a64fe8c8-4bd6-51b3-a29a-54cfd4601131
DOI: 10.1101/2024.08.16.608206

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