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Article

Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.

Cancer discovery - 1 Nov 2018

Eckhardt Manon, Zhang Wei, Gross Andrew M, Von Dollen John, Johnson Jeffrey R, Franks-Skiba Kathleen E, Swaney Danielle L, Johnson Tasha L, Jang Gwendolyn M, Shah Priya S, Brand Toni M, Archambault Jacques, Kreisberg Jason F, Grandis Jennifer R, Ideker Trey, Krogan Nevan J

Abstract excerpt

We have mapped a global network of virus-host protein interactions by purification of the complete set of human papillomavirus (HPV) proteins in multiple cell lines followed by mass spectrometry analysis. Integration of this map with tumor genome atlases shows that the virus targets human proteins frequently mutated in HPV- but not HPV+ cancers, providing a unique opportunity to identify novel oncogenic events...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30209081
DOI: 10.1158/2159-8290.CD-17-1018
PMCID: PMC6375299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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