Article

Human papillomavirus integration transforms chromatin to drive oncogenesis

2020-02-13

Abstract excerpt

Human papillomavirus (HPV) drives almost all cervical cancers and up to ∼70% of head and neck cancers. Frequent integration into the host genome occurs only for tumourigenic strains of HPV. We hypothesized that changes in the epigenome and transcriptome contribute to the tumourigenicity of HPV. We found that viral integration events often occurred along with changes in chromatin state and expression of genes near...

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Literature Corpus work: 7b95bc4f-b81a-5cf9-98d8-3e950a3b5073
DOI: 10.1101/2020.02.12.942755

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