Article

ZNF582 inactivation unleashes HERVH-driven NF-kB signaling in cervical cancer

2026-07-07

Abstract excerpt

<title>Abstract</title> <p>Persistent high-risk HPV infection initiates cervical cancer, but the host-cell programs that convert reversible epithelial lesions into invasive disease remain unclear. Here we identify HERVH as an endogenous retroviral amplifier of NF-κB signaling in cervical cancer. Pan-cancer analyses identified ZNF582, a cervical cancer triage marker, as a candidate repressor of HERVH. During cervi...

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Literature Corpus work: b7b8b80b-8e9e-5180-9cfd-f05dc7288d65
DOI: 10.21203/rs.3.rs-10229168/v1

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