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Article

Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs

30 Nov 2021

Abstract excerpt

Oncogenic human papillomavirus (HPV) genomes are often integrated into host chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single copy or as tandem repeats of viral DNA interspersed with, or without, host DNA. Integration occurs frequently in common fragile sites susceptible to tandem repeat formation and the flanking or interspersed host DNA often contains transcriptional enhancer...

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PMID: 34848725
DOI: 10.1038/s41525-021-00264-y

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