Article
Highly efficient generation of sheep with a defined FecBB mutation via adenine base editing.
Genetics, selection, evolution : GSE - 1 Jul 2020
Zhou Shiwei, Ding Yige, Liu Jiao, Liu Yao, Zhao Xiaoe, Li Guanwei, Zhang Chenguang, Li Chao, Wang Ying, Kalds Peter, Gao Yawei, Zong Bo, Huang Xiaoyu, Huang Shuhong, Yu Honghao, Kou Qifang, Petersen Bjoern, Huang Xingxu, Wang Xiaolong, Ma Baohua, Chen Yulin
Abstract excerpt
Base editing has the potential to improve important economic traits in agriculture and can precisely convert single nucleotides in DNA or RNA sequences into minimal double-strand DNA breaks (DSB). Adenine base editors (ABE) have recently emerged as a base editing tool for the conversion of targeted A:T to G:C, but have not yet been used in sheep. ABEmax is one of the latest versions of ABE, which consists of a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.