Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosomal profiles of gene expression in Huntington's disease.

Brain : a journal of neurology - 1 Feb 2008

Anderson Alexander N, Roncaroli Federico, Hodges Angela, Deprez Manuel, Turkheimer Federico E

Abstract excerpt

Recent studies suggested that Huntington's disease is due to aberrant interactions between mutant huntingtin protein, transcription factors and transcriptional co-activators resulting in widespread transcriptional dysregulation. Mutant huntingtin also interacts with histone acetyltransferases, consequently interfering with the acetylation and deacetylation states of histones. Because histone modifications and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caudate Nucleus
Share to Chromosome Aberrations
Share to Data Interpretation, Statistical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Huntingtin Protein

Share to Huntington Disease

Share to Nerve Tissue Proteins

Share to Oligonucleotide Array Sequence Analysis

Source

Identifiers

PMID: 18156153
DOI: 10.1093/brain/awm312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosomal profiles of gene expression in Huntington's disease.PMID 18156153Read ↗

A putative role for genome-wide epigenetic regulatory mechanisms in Huntington’s disease: A computational assessmentSemantic proximity Read ↗

Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease Mouse ModelsSemantic proximity Read ↗

Transcriptional modulator <i>H2A histone family, member Y</i> ( <i>H2AFY</i> ) marks Huntington disease activity in man and mouseSemantic proximity Read ↗

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington diseaseSemantic proximity Read ↗

Transcriptional dysregulation in Huntington’s diseaseSemantic proximity Read ↗

Complex small-world regulatory networks emerge from the 3D organisation of the human genomeSemantic proximity Read ↗

A common gene expression signature in Huntington’s disease patient brain regionsSemantic proximity Read ↗

Complex small-world regulatory networks emerge from the 3D organisation of the human genomeSemantic proximity Read ↗

Inference of Genomic Landscapes using Ordered Hidden Markov Models with Emission Densities (oHMMed)Semantic proximity Read ↗

Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.Semantic proximity Read ↗

Polyglutamine (polyQ) disordersSemantic proximity Read ↗

Microarray profiling of hypothalamic gene expression changes in Huntington’s disease mouse modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.