Article
Paired immunoglobulin-like receptor B regulates platelet activation.
Blood - 9 Oct 2014
Fan Xuemei, Shi Panlai, Dai Jing, Lu Yeling, Chen Xue, Liu Xiaoye, Zhang Kandi, Wu Xiaolin, Sun Yueping, Wang Kemin, Zhu Li, Zhang Cheng Cheng, Zhang Junfeng, Chen Guo-Qiang, Zheng Junke, Liu Junling
Abstract excerpt
Murine paired immunoglobulin-like receptors B (PIRB), as the ortholog of human leukocyte immunoglobulin-like receptor B2 (LILRB2), is involved in a variety of biological functions. Here, we found that PIRB and LILRB2 were expressed in mouse and human platelets, respectively. PIRB intracellular domain deletion (PIRB-TM) mice had thrombocythemia and significantly higher proportions of megakaryocytes in bone marrow....
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