Article

uniSynK: a ratio-optimized bicistronic chemically induced dimerization tool for robust induction of dendritic spine enlargement

2026-05-06

Abstract excerpt

Synaptic plasticity is widely implicated in learning and brain-state regulation. Although correlations between synaptic modifications and diverse brain functions have been extensively reported, establishing causality requires tools that can directly and selectively perturb synapses in vivo. Recently, the chemogenetic actuator SYNCit-K (SynK) enabled causal induction of dendritic spine enlargement and synaptic pote...

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Literature Corpus work: 14d2d775-d5f5-5fcb-8973-3a2feed483ca
DOI: 10.64898/2026.05.02.720486

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