Article
Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2004
Dittgen Tanjew, Nimmerjahn Axel, Komai Shoji, Licznerski Pawel, Waters Jack, Margrie Troy W, Helmchen Fritjof, Denk Winfried, Brecht Michael, Osten Pavel
Abstract excerpt
It is becoming increasingly clear that single cortical neurons encode complex and behaviorally relevant signals, but efficient means to study gene functions in small networks and single neurons in vivo are still lacking. Here, we establish a method for genetic manipulation and subsequent phenotypic analysis of individual cortical neurons in vivo. First, lentiviral vectors are used for neuron-specific gene...
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