Essential functions of synapsins I and II in synaptic vesicle regulation.

doi:10.1038/375488a0

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Article

Essential functions of synapsins I and II in synaptic vesicle regulation.

Nature - 8 Jun 1995

Rosahl T W, Spillane D, Missler M, Herz J, Selig D K, Wolff J R, Hammer R E, Malenka R C, Südhof T C

Abstract excerpt

Synaptic vesicles are coated by synapsins, phosphoproteins that account for 9% of the vesicle protein. To analyse the functions of these proteins, we have studied knockout mice lacking either synapsin I, synapsin II, or both. Mice lacking synapsins are viable and fertile with no gross anatomical...

Topics

Animals
Base Sequence
Brain
Female
Immunoblotting
Male
Membrane Fusion
Mice
Mice, Knockout
Molecular Sequence Data
Neurites
Neurotransmitter Agents
Oligodeoxyribonucleotides
Phenotype
Seizures
Synapsins
Synaptic Transmission
Synaptic Vesicles

Source

Open in PubMed

Identifiers

PMID: 7777057
DOI: 10.1038/375488a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7777057-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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