Article

When does high-dose antimicrobial chemotherapy prevent the evolution of resistance?

2015-06-03

Abstract excerpt

High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical and theoretical studies have begun to challenge this view. We show how high-dose chemotherapy engenders opposing evolutionary processes involving the mutational input of resistant strains and their release from ecological competition. Whether such therapy provides the best approach f...

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Identifiers and source

Literature Corpus work: 14c3644f-d957-59c5-a17b-8d48393c0f6b
DOI: 10.1101/020321

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