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Article

Drug concentration heterogeneity facilitates the evolution of drug resistance.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

Kepler T B, Perelson A S

Abstract excerpt

Pathogenic microorganisms use Darwinian processes to circumvent attempts at their control through chemotherapy. In the case of HIV-1 infection, in which drug resistance is a continuing problem, we show that in one-compartment systems, there is a relatively narrow window of drug concentrations that allows evolution of resistant variants. When the system is enlarged to two spatially distinct compartments held at...

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Identifiers

PMID: 9751697
DOI: 10.1073/pnas.95.20.11514
PMCID: PMC21672

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Source receipt: pubmed, retrieved 7 Sept 2026.

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